N-methyl-N-{[(2S)-oxiran-2-yl]methyl}methanesulfonamide
N-methyl-N-[(2S)-oxiranylmethyl]-Methanesulfonamide
CAS: 866777-98-2
Molecular Formula: C5H11NO3S
N-methyl-N-{[(2S)-oxiran-2-yl]methyl}methanesulfonamide - Names and Identifiers
N-methyl-N-{[(2S)-oxiran-2-yl]methyl}methanesulfonamide - Physico-chemical Properties
| Molecular Formula | C5H11NO3S |
| Molar Mass | 165.21 |
N-methyl-N-{[(2S)-oxiran-2-yl]methyl}methanesulfonamide - Introduction
N-methyl-N-[(2S)-oxiranylmethyl]-Methanesulfonamide is an organic compound with the chemical formula C5H11NO4S. Its nature is as follows:
Appearance: Colorless to light yellow crystalline powder;
Solubility: Soluble in polar organic solvents, such as alcohols and ketones;
Melting point: about 70-75°C.
N-methyl-N-[(2S)-oxiranylmethyl]-Methanesulfonamide is commonly used as a reagent in organic synthesis and has the following main applications:
1. as a catalyst for stereoselective reactions: due to its epoxy structure and methylsulfonyl group, it can selectively catalyze the reaction of chiral compounds without affecting the chiral receptor group.
The method for preparing N-methyl-N-[(2S)-oxiranylmethyl]-Methanesulfonamide is as follows:
First, 2-oxopropyl methanesulfonamide is reacted with an electrophilic reagent to generate a stable electrophilic adduct. Next, the stable electrophilic adduct of the previous step is reacted with a nucleophile (e. g., borane) to form N-methyl-N-[(2S)-oxiranylmethyl]-Methanesulfonamide.
Regarding safety information, N-methyl-N-[(2S)-oxiranylmethyl]-Methanesulfonamide is an organic compound, the following safety precautions should be noted:
1. tolerance to irritation: this compound may cause irritation to the skin, eyes and respiratory tract, and may cause allergic reactions. During handling and handling, direct contact should be avoided.
2. Avoid inhalation: This compound may produce toxic or irritating gases, fumes or vapors during handling or use. You should operate in a well-ventilated area and wear respiratory protection.
3. fire prevention measures: this compound is a combustible substance. Avoid contact with open flames or high temperature substances, and keep away from ignition sources.
4. storage and handling: it should be stored in a closed, cool, dry place, away from oxidants and flammable substances. When disposing of waste, it should be disposed of in accordance with local regulations.
Appearance: Colorless to light yellow crystalline powder;
Solubility: Soluble in polar organic solvents, such as alcohols and ketones;
Melting point: about 70-75°C.
N-methyl-N-[(2S)-oxiranylmethyl]-Methanesulfonamide is commonly used as a reagent in organic synthesis and has the following main applications:
1. as a catalyst for stereoselective reactions: due to its epoxy structure and methylsulfonyl group, it can selectively catalyze the reaction of chiral compounds without affecting the chiral receptor group.
The method for preparing N-methyl-N-[(2S)-oxiranylmethyl]-Methanesulfonamide is as follows:
First, 2-oxopropyl methanesulfonamide is reacted with an electrophilic reagent to generate a stable electrophilic adduct. Next, the stable electrophilic adduct of the previous step is reacted with a nucleophile (e. g., borane) to form N-methyl-N-[(2S)-oxiranylmethyl]-Methanesulfonamide.
Regarding safety information, N-methyl-N-[(2S)-oxiranylmethyl]-Methanesulfonamide is an organic compound, the following safety precautions should be noted:
1. tolerance to irritation: this compound may cause irritation to the skin, eyes and respiratory tract, and may cause allergic reactions. During handling and handling, direct contact should be avoided.
2. Avoid inhalation: This compound may produce toxic or irritating gases, fumes or vapors during handling or use. You should operate in a well-ventilated area and wear respiratory protection.
3. fire prevention measures: this compound is a combustible substance. Avoid contact with open flames or high temperature substances, and keep away from ignition sources.
4. storage and handling: it should be stored in a closed, cool, dry place, away from oxidants and flammable substances. When disposing of waste, it should be disposed of in accordance with local regulations.
Last Update：2024-04-10 22:29:15
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